Past exam of the mathematical physiology course of the University of Oxford 2011 2 c Solution 2026-10-31
During ejection the mitral valve is closed, so . Adding the arterial and ventricular balances cancels aortic flow:where the last approximation assumes .
Model the rapid contraction as a switch to approximately constant systolic elastance , with the systolic ventricular compliance. A sufficiently small aortic-valve resistance makes after a short pressure-equalization transient. The systolic pressure must be high enough to open the valve, . During that transient neglect systemic runoff. Conservation of combined arterial and stressed ventricular volume givessoThis is an approximation across a rapid transient, not a discontinuity at finite valve resistance. The subsequent common pressure obeys , givingThe source's in this expression denotes the same systemic resistance .
At the end of firing, the remaining ventricular volume is . The stroke volume is , henceThe assumptions are a closed mitral valve throughout ejection, negligible venous pressure, rapid valve equalization relative to systemic runoff, and nearly constant systolic elastance during the interval measured by . These give the ventricular ejection pressure and stroke-volume approximation.
Stroke volume 2026-10-31
After a rapid switch to systolic compliance , negligible valve resistance equalizes arterial and ventricular pressures. Neglecting runoff during this short stage conserves combined stored volume and gives the displayed pressure. Thereafter, with closed mitral valve, negligible venous pressure and constant , the pressure decays as . At firing duration , the stroke volume is . Each approximation follows from an explicit valve or time-scale separation condition.