= T. A. Springer
{c}
<T. A. Springer> contributed to experiments connecting immune-cell surface <proteins> with recognition and <cell adhesion>. In a 1982 study with <D. I. Beller> and collaborators, selective <antibody> blocking related <Mac-1> to binding of targets bearing <iC3b>, a fragment involved in the <complement system>.<Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others>[Abstract: selective inhibition of complement-receptor-mediated rosetting]{ref}
With <M. L. Dustin>, <T. A. Springer> later investigated how stimulating the <T-cell receptor> changes adhesion through <LFA-1>. The 1989 experiments found a rapid, transient increase in adhesion strength. This supplied a mechanism for coordinating target recognition with sticking and subsequent release, rather than treating the presence of an adhesion <protein> as a fixed measure of how strongly a cell will bind.<T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 by M. L. Dustin and T. A. Springer>[Abstract; Nature 341, 619–624, 1989]{ref}
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