T. A. Springer contributed to experiments connecting immune-cell surface proteins with recognition and cell adhesion. In a 1982 study with D. I. Beller and collaborators, selective antibody blocking related Mac-1 to binding of targets bearing iC3b, a fragment involved in the complement system.[ref]
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others. Abstract: selective inhibition of complement-receptor-mediated rosetting
With M. L. Dustin, T. A. Springer later investigated how stimulating the T-cell receptor changes adhesion through LFA-1. The 1989 experiments found a rapid, transient increase in adhesion strength. This supplied a mechanism for coordinating target recognition with sticking and subsequent release, rather than treating the presence of an adhesion protein as a fixed measure of how strongly a cell will bind.[ref]
- Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others
- Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1) by Steven D. Marlin and Timothy A. Springer
- T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 by M. L. Dustin and T. A. Springer
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T. A. Springer is a prominent American geneticist and biologist known for his work in the field of plant genetics and developmental biology. He has contributed significantly to the understanding of genetic mechanisms in plants, including the study of transposable elements and their roles in genome evolution. Springer has published numerous research papers and has been involved in various academic and scientific endeavors throughout his career.