For the three-region calcium nullcline, define
For , , as , and . Thus there is exactly one positive root for every positive . The curve starts at the origin and initially satisfies .
For , let solve and put , , . Explicitly, with ,
In particular and for small .
On the large- branch away from the crossing, replace by one. This gives where this is large and positive. Near retain the next term and linearize :
Finally where the leak is negligible compared with the other terms, , so on the side . These are overlapping asymptotic descriptions with different validity ranges, not three exact disconnected curves. The curve rises to a large peak, falls sharply near , then approaches a small finite level as . At leading small- order that last level is .
Figure 1.
Calcium nullcline and its three asymptotic regions; full curve and transition zoom
. Details.