= Ubiquitin-conjugating enzyme
= E2 enzyme
{c}
{synonym}
A <ubiquitin-conjugating enzyme>, or E2, accepts activated <ubiquitin> from a <ubiquitin-activating enzyme> onto a catalytic <cysteine>. It then works with a <ubiquitin ligase> to transfer <ubiquitin> onward. Pairing between E2 and E3 helps determine which modification is assembled. This <division of labour> separates initial energy-dependent activation from later <substrate> selection and transfer. <The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper/Protein Degradation>[E1-E2-E3 ubiquitin-transfer cascade]{ref}
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