A ubiquitin-conjugating enzyme, or E2, accepts activated ubiquitin from a ubiquitin-activating enzyme onto a catalytic cysteine. It then works with a ubiquitin ligase to transfer ubiquitin onward. Pairing between E2 and E3 helps determine which modification is assembled. This division of labour separates initial energy-dependent activation from later substrate selection and transfer. [ref]
Protein Degradation. E1-E2-E3 ubiquitin-transfer cascade
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