{c}

<UPF3> is a conserved factor associated with <nonsense-mediated decay>. In mammalian exon-junction-linked surveillance, <UPF3> <proteins> can connect an exon-junction-associated assembly with <UPF2> and downstream <UPF1>-dependent events. Human <paralogues> UPF3A and UPF3B differ in context and activity, so the generic label should not imply identical contributions in every <cell>. Artificial tethering experiments helped establish that positioning UPF factors downstream of a termination codon can promote decay. <Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon by Jens Lykke-Andersen and others>[2000, downstream tethering of human UPF proteins]{ref}


 UPF3 (source code)