Polar surface area
= Polar surface area
{wiki=Polar_surface_area}
Polar surface area (PSA) is a molecular descriptor used in cheminformatics and drug design to characterize the surface area of a molecule that is polar in nature. It specifically measures the area of a molecule that is accessible to solvent molecules (often water), focusing on the polar atoms such as nitrogen, oxygen, and halogens, which can participate in hydrogen bonding and other polar interactions.