The Chemical Shift Index (CSI) is a concept primarily used in the field of NMR (nuclear magnetic resonance) spectroscopy, particularly in the analysis and interpretation of protein structures and their dynamics. It is a way to evaluate the local environment of specific nuclei—usually protons (hydrogens)—in a molecule, and is derived from the chemical shifts observed in the NMR spectrum. The CSI is often utilized to provide insights into the secondary structure of proteins.
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