 G protein-coupled inwardly rectifying potassium channel

G protein-coupled inwardly rectifying potassium channels (GIRKs or K_IR channels) are a type of ion channel that play a crucial role in regulating the electrical activity of cells, particularly in the heart and nervous system. These channels are activated by G protein-coupled receptors (GPCRs) and help mediate the effects of neurotransmitters and hormones on cell excitability.