 Mitochondrial unfolded protein response

The mitochondrial unfolded protein response (UPRmt) is a cellular signaling pathway that is activated in response to the accumulation of misfolded or unfolded proteins within the mitochondria. This response is critical for maintaining mitochondrial function and overall cellular health. ### Key Features of UPRmt: 1. **Activation**: The UPRmt is triggered when mitochondrial stress occurs, which can be caused by various factors such as oxidative stress, proteotoxic stress, or damages to mitochondrial DNA.