Some of the most notable ones:
- 1942: Chicago Pile-1: the first human-made nuclear chain reaction.
- 1943: X-10 Graphite Reactor: an intermediate step between the nuclear chain reaction prototype Chicago Pile-1 and the full blown mass production at Hanford site. Located in the Oak Ridge National Laboratory.
- 1944: B Reactor at the Hanford site produced the plutonium used for Trinity and Fat Man
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