Spectrum bias refers to a phenomenon in diagnostic research where the performance of a diagnostic test or a medical screening tool varies depending on the characteristics of the population being tested. Specifically, this bias can occur when the sample of patients evaluated in a study does not accurately represent the broader population that will ultimately undergo testing in clinical practice. There are a few key factors that contribute to spectrum bias: 1. **Patient Selection**: If a study includes patients with certain characteristics (e.g.
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