The Bürgi–Dunitz angle refers to a specific dihedral angle observed in the context of molecular structures, particularly in the study of how nucleophiles approach electrophiles during chemical reactions. It is defined as the angle between the plane of a nucleophile (such as a carbonyl or amine) and the bond axis connecting the electrophile (such as carbon in an electrophilic center) to the nucleophile.
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The Bürgi-Dunitz angle describes the oblique approach of a nucleophile toward a carbonyl carbon, conventionally measured relative to C=O. A typical trajectory is near , with the optimum depending on the system.