GABRB2 is a gene that encodes the beta-2 subunit of the gamma-aminobutyric acid (GABA) receptor, which is a major inhibitory neurotransmitter receptor in the central nervous system. GABA receptors are integral in regulating neuronal excitability and play a key role in reducing neuronal excitability throughout the nervous system. The GABA receptor is a pentameric complex, meaning it is composed of five subunits.

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