Isabella Karle was an influential American scientist known for her work in the fields of chemistry and crystallography. Born on December 12, 1921, in Detroit, Michigan, she made significant contributions to the study of molecular structure and the development of X-ray crystallography techniques. Karle co-developed methods that advanced the analysis of complex biological molecules, including proteins and nucleic acids. She was also a prominent figure at the Naval Research Laboratory, where she conducted extensive research throughout her career.

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