An open-label trial is a type of clinical study in which both the researchers and participants are aware of the treatment being administered. Unlike blinded trials, where participants or researchers may not know which treatment is being given (to minimize bias), open-label trials provide full transparency. Open-label trials can be useful in various contexts, such as: 1. **Real-world settings:** They often reflect scenarios where patients receive treatment in standard practice rather than within the controlled environment of a double-blind trial.
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