Reference materials for stable isotope analysis are substances with well-characterized isotopic compositions that are used to calibrate and validate analytical instruments and methods involved in the measurement of stable isotopes. These materials help ensure that the results obtained from isotope analyses are accurate, reproducible, and comparable across different laboratories. ### Key Features of Reference Materials: 1. **Characterization**: Reference materials have precisely determined isotopic ratios, which are established through consensus methods or extensive inter-laboratory comparison.

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