Threading (protein sequence)

In the context of protein sequences, "threading" refers to a computational technique used in bioinformatics to predict protein structure based on known structures of other proteins. This method is particularly useful for proteins whose three-dimensional structures have not yet been determined experimentally. Here’s a brief overview of how threading works: 1. **Alignment with Known Structures**: Threading involves aligning a target protein sequence with a library of protein structures that have been previously solved (often referred to as a structure database).