A component of the active eukaryotic CMG replicative helicase.
It works with MCM2-7 and GINS in the CMG helicase. Assembly and activation of this complex connect licensed replication origins to an operating fork; the presence of one component on chromatin does not alone establish active unwinding. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 4–7, chromatin, replication and gene regulation
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