A guanine-nucleotide exchange factor involved in local activation of RhoA during animal cytokinesis.
Spatially restricted RhoA activation helps organize the contractile machinery at the cleavage site. The exchange factor therefore links positional information from the division apparatus to local cytoskeletal force generation. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 3, 6 and 15, protein function, translation and cell signalling
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