A replication-control protein whose regulated degradation motif is used in the original Fucci reporters.
Its normal role includes restricting replication licensing through interaction with Cdt1. In a Fucci construct, a selected degradation region is used to report regulated turnover; the reporter signal should not be equated with the full native protein’s activity. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 17, Control of DNA Replication
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