Lethal giant larvae denotes a conserved polarity-protein family first characterized in Drosophila. Its members help organize cortical domains and epithelial polarity, with activity and localization regulated partly through phosphorylation. Mammalian LLGL proteins are related components rather than literal larval structures. Their contribution depends on cellular context, so polarity effects and effects on proliferation should be measured separately. [ref]
NCBI Gene by the National Library of Medicine. Homo sapiens, LLGL1 record, Summary and linked functional evidence
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