A micelle is a finite aggregate of amphiphiles in a solvent. In an ordinary aqueous micelle, hydrophobic tails occupy the interior and hydrophilic heads contact the surrounding water. Association can lower the Gibbs free energy by reducing unfavorable tail exposure, despite loss of molecular translational entropy. Head-group interactions and chain packing help select the aggregate size and shape. A micelle has a filled tail-rich core, unlike a lipid vesicle with a solvent-filled interior bounded by a lipid bilayer.
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