Mieczysław Mąkosza coauthored mechanistic work on vicarious nucleophilic substitution of hydrogen in nitroarenes. Isotope effects, base dependence, and competing substitution pathways support reversible addition followed by base-induced elimination.
The evidence distinguishes that sequence from a proposed hydride-shift alternative. Combining several measurements is valuable because one product structure can be compatible with more than one imagined mechanism.[ref]
Portrait of Mieczysław Mąkosza
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