Munc18 denotes a Sec1-Munc18 family of proteins that regulate SNARE-dependent membrane fusion. Different isoforms interact with particular syntaxin-associated pathways; Munc18-1 is prominent in neuronal secretion, while Munc18c participates in other trafficking systems. Binding to a syntaxin and promoting productive fusion are separable activities. Reconstitution experiments test how these regulators favour assembly of the appropriate fusion machinery. [ref]
Selective activation of cognate SNAREpins by Sec1-Munc18 proteins by Jingshi Shen and others. 2007, purified SNARE fusion systems and cognate SM-protein effects
New to topics? Read the docs here!