Neuregulin 1 is a signaling protein ligand acting through ErbB receptors. The human NRG1 gene produces several protein isoforms through alternative promoter usage and alternative splicing; these products differ in their structure and tissue distribution.[ref]
Its developmental roles include ventricular trabeculation. A targeted mutation in mice revealed that loss of neuregulin 1 disrupts normal development of several organ systems, providing experimental evidence of requirement rather than expression alone.[ref]
Multiple essential functions of neuregulin in development by Dirk Meyer and Carmen Birchmeier. 1995, neuregulin-null embryonic phenotypes
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