Solution
ID: past-exam-of-the-biological-physics-course-of-the-university-of-oxford/2022/4/c/solution
Past exam of the biological physics course of the University of Oxford 2022 4 c Solution by
Codex 0 2026-10-25
For a uniform distribution of phases along one period, average the ensemble force :Using the negligible-carry-over form in b givesConsequentlywhere . This is the printed expression to the accuracy justified by the velocity condition.
It is not an exact identity for the periodic problem at arbitrary . Keeping instead givesFor a concrete counterexample outside the small-velocity approximation, choose and . Then the exact periodic value is about , whereas the printed reset expression is about . The discrepancy is due to nonzero incoming occupancy, not an integration sign change.
As , both and diverge, and both formulas giveThe bound population occupies the downhill binding region, while occupancy on the uphill region is confined to a vanishing boundary layer. A nonzero limiting stall force is compatible with zero mechanical power . The spatially restricted binding and uniform unbinding do not obey local detailed balance for this sawtooth free energy: a passive equilibrium model would require to reflect the local energy difference and not vanish on an interval of finite energy. This is a driven or prescribed-kinetics motor model; the equilibrium relation in a cannot be imposed on it without an energy supply and additional states.
New to topics? Read the docs here!