Solution

ID: past-exam-of-the-mathematical-and-computational-biology-course-of-the-university-of-cambridge/2024/paper-1/a1/d/solution

Write . The score function is
Setting it to zero gives the maximum-likelihood estimator
This lies above . The observed Fisher information is
Consequently the log-likelihood is strictly concave throughout its domain. Its stationary point is the unique global maximum, not merely a candidate local maximum. Indeed the log-likelihood tends to minus infinity as either or .

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