Solution

ID: past-exam-of-the-mathematical-and-computational-biology-course-of-the-university-of-cambridge/2024/paper-1/a1/f/solution

Here . The maximum-likelihood estimate and estimated standard error from the observed Fisher information are
The 95% Wald confidence interval is therefore
The whole reported confidence interval lies in , though its lower endpoint is close to the boundary. With only four observations, the normal approximation underlying this Wald confidence interval need not provide accurate 95% coverage.

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