Solution

ID: past-exam-of-the-mathematical-and-computational-biology-course-of-the-university-of-cambridge/2025/paper-1/2/c/solution

The score function and the observed Fisher information are
Solving the score equation gives the maximum-likelihood estimate
The positive observed Fisher information means that the log-likelihood is strictly concave on . Its unique stationary point is therefore the global maximum. Equivalently, the score function changes from positive to negative at this point. At the estimate, .

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