Solution

ID: past-exam-of-the-mathematics-course-of-the-university-of-cambridge/2005/iii/paper-44/2/b/solution

Condition on a frailty random variable value . Integrating the conditional hazard function gives , so the conditional survivor function is
Average this conditional probability over the common frailty density :
By definition the Laplace transform of is . Hence
This averages survivor functions, not hazards. Differentiating its logarithm, when justified, gives
Thus the population hazard function uses the mean frailty among current survivors, explaining why a conditional proportional hazards model may cease to be proportional after frailty is integrated out.

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