 Solution

Allowed through an s-channel W boson. The initial up quark and down antiquark annihilate into a virtual $W^{+}$, which produces the final charm quark and strange antiquark. The two weak charged current vertices contain the nonzero CKM matrix elements $V_{ud}$ and $V_{cs}$, with complex conjugations determined by fermion-flow conventions.

The left panel shows the unique physical-particle tree-level Feynman diagram. A neutral exchanged gauge boson cannot connect these charged annihilation currents, and flavour-diagonal neutral vertices cannot turn an up quark into a charm quark. There is no additional elementary charged scalar in the minimal Standard Model.