An inhibitory regulator of separase. Its regulated destruction helps permit sister-chromatid separation.
Destruction is controlled by the anaphase-promoting complex, linking the cell-cycle decision to activation of the protease that removes a cohesion barrier. This makes protein turnover part of a switch that permits physical chromosome separation. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 3, 6 and 15, protein function, translation and cell signalling
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