With Telescopes however, it is possible. www.quora.com/Can-we-distinguish-individual-stars-in-other-galaxies-or-would-it-be-equivalent-to-say-we-know-there-are-other-forests-of-stars-galaxies-but-we-cant-tell-the-individual-trees-stars-What-is-the-farthest-individual/answer/Jerzy-Micha%C5%82-Pawlak contains an amazing answer that mentions two special cases of the furthest ones:
But what we can definitely see are globular clusters of galaxies. E.g. the article en.wikipedia.org/wiki/Messier_87 basically gauges the size of galaxies by the number of globular clusters that they contain.
The Large Magellanic Cloud stands out as the brightest thing we can see from outside the Milky Way by far!
Some stars are so close that we can actually see their angles move with time due to the relative motion between them and the Sun, e.g. Proxima Centauri!

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