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Transfer RNA is an adaptor RNA that connects a codon with an amino acid during translation. Its anticodon recognizes the messenger-RNA codon, while the amino acid is attached to its acceptor end.
Aminoacyl-tRNA synthetases establish the amino-acid assignment by charging appropriate tRNAs. Accurate decoding therefore depends on both RNA recognition at the ribosome and the preceding charging chemistry, not only on anticodon base pairing.