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Yuan Zhuang coauthored a 1986 study with A. M. Weiner that used a compensatory base change to investigate RNA splicing. Duke's institutional publication record explicitly connects the initial-only byline Y. Zhuang to Yuan Zhuang.^[ref]

The experiment compared altered splice donor sites with altered U1 small nuclear RNA. In cells receiving the corresponding constructs, one compensating combination strongly restored donor use, whereas another gave very weak rescue. These observations supported direct base pairing but showed that matching the two RNA sequences was insufficient to guarantee productive RNA splicing.^[ref]

For an original quantitative illustration of rescue, suppose a hypothetical assay measures a processed fraction of $0.80$ in a reference, $0.10$ after one perturbation and $0.60$ after a compensating perturbation. The fraction of the lost response recovered would beThat is approximately $71\%$ recovery of the loss, despite a final processed fraction of $60\%$. These invented numbers illustrate why absolute processing and recovery relative to a reference answer different questions; they are not measurements from the paper.