Past exam of the mathematics course of the University of Cambridge 2015 iii Paper 35 3 a Solution Created 2026-10-03 Updated 2026-10-06
Let be the infection time and its incubation delay, with independent delays having probability density function . Each infection contributes to the symptom-onset intensity according to its delay density. Back-calculation of infection incidence uses the convolutionObserved onset intensity is infection intensity convolved with the incubation distribution. If infections begin at a known , take for , reducing the first integral's lower limit to . Otherwise past infections must be included; the observation window's start need not be the infection process's start.
Past exam of the mathematics course of the University of Cambridge 2015 iii Paper 35 3 c Solution Created 2026-10-03 Updated 2026-10-06
For the stated scale-parameterisation of the Weibull distribution, its incubation survivor function is for , with . The continuous back-calculation of infection incidence equation becomesSet before the infection process's start if one is specified. For the equal-width endpoint approximation, integrate the incubation density over each delay bin:Thus the discrete Weibull equation isFor unequal intervals replace by . These are probabilities, not point evaluations of a density; no additional factor of is needed after bin integration.
Past exam of the mathematics course of the University of Cambridge 2015 iii Paper 35 3 e Solution Created 2026-10-03 Updated 2026-10-06
With the onset means defined by the discrete back-calculation of infection incidence, the independent Poisson observation model yields the product likelihoodFor positive means its log-likelihood is . A zero mean assigns probability one to a zero count and zero to a positive count. Any unknown pre-observation infection history must be parameterised or supplied as well; it cannot silently be excluded merely because the observation series starts at .