Charles R. Cantor coauthored the 2000 paper constructing a genetic toggle switch with Timothy S. Gardner and James J. Collins. The reported system coupled genetic regulation to a bistable memory-like response in Escherichia coli.[ref]
A Boston University research account published in 2003 identifies Cantor with the Center for Advanced Biotechnology and describes work on DNA analysis and haplotypes.[ref]
Dynamic solutions to physiological problems by David J. Craig. Genes in context and named portrait caption
A simple genetics example makes the measurement problem tangible. The two arrangements
AB/ab and Ab/aB both produce an individual with genotype A/a at one site and B/b at another. They nevertheless place the variants on different chromosome copies. Measuring the unphased genotype at each site therefore does not by itself recover the haplotypes.The example illustrates a reusable distinction between identifying individual sequence variants and determining their joint arrangement. The institutional account concerns methods intended to obtain that longer-range genetic information. Together with the coauthored switch study, it shows two different quantitative questions in biotechnology: reconstructing the organization of genetic material and constructing a network with a chosen dynamical response.
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