Clinician-rated global severity and improvement measures. A rating of much or very much improved on the improvement scale is a response endpoint, not automatically freedom from the original diagnosis.[ref]
The Clinical Global Impression–Improvement scale is a clinician’s ordered rating of change relative to a specified baseline. Its seven categories run from very much improved through no change to very much worse. It summarizes an overall judgment rather than measuring a fixed number of symptoms. In the childhood-anxiety trial, much or very much improved defined a treatment-response endpoint; that classification was distinct from establishing absence of every diagnosis or impairment. [ref]

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