Lineage tracing that identifies descendants of a single ancestor. A labelled group is informative about a clone only if labelling collisions and independent activation are excluded.
The distribution of descendant counts per clone. Differences can arise from proliferation, survival, migration or sampling rather than altered fate choice alone.
Labelling few enough founder cells to resolve individual clones. The acceptable density depends on spatial mixing, label diversity and the chance of independent activation.
Production of more than one differentiated cell type from one confirmed progenitor. Several separately labelled unipotent cells can imitate this pattern if the label is not unique.
Competition among labelled clones with equivalent average reproductive behaviour. Clone extinction can coexist with tissue maintenance, and surviving clones form a selected subset of all initial clones.
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