Psychological treatment using an individual formulation and collaborative examination of difficulties associated with psychotic experiences. Symptom-specific protocols, general support and usual care provide different comparisons for assessing incremental benefit.
A blended digital and face-to-face reasoning intervention for paranoia. Its 2021 trial did not establish a significant benefit on the prespecified total paranoia score at 24 weeks, despite favourable secondary results. This illustrates why endpoint, timing and process engagement matter when evaluating innovation.[ref]
Effects of SlowMo, a Blended Digital Therapy Targeting Reasoning, on Paranoia Among People With Psychosis: A Randomized Clinical Trial by Philippa Garety and others. JAMA Psychiatry 78, 714–725; 361 in analysis, prespecified 24-week GPTS total endpoint and secondary outcomes
A personalised intervention for persistent persecutory delusions, combining modules selected to address relevant maintaining processes. Its active control trial compared it with same-therapist befriending alongside usual care. The continuous conviction result and categorical recovery comparison require separate interpretation.[ref]
Comparison of a theoretically driven cognitive therapy (the Feeling Safe Programme) with befriending for the treatment of persistent persecutory delusions: a parallel, single-blind, randomised controlled trial by Daniel Freeman and others. Lancet Psychiatry 8, 696–707; 130 patients, same-therapist befriending, six-month continuous conviction and categorical recovery distinction
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