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Discs large denotes a conserved scaffold-protein family involved in organizing cell junctions, polarity and signalling complexes. Its interaction domains help assemble different partners at particular cellular locations. The original name comes from mutant phenotypes in Drosophila imaginal discs; related mammalian proteins have additional tissue-specific roles. A scaffold can influence a pathway by positioning components even without catalysing a chemical reaction. ^[ref]

Basolateral polarity regulators including Scribble, Discs large and Lethal giant larvae. Their interactions oppose inappropriate apical-domain expansion while supporting other tissue-specific functions.