Dong Wang is a researcher in structural biology studying transcription and its relationship to DNA repair. His work combines structural and biochemical methods to investigate how molecular machines copy genetic information and respond to damage.[ref]
Dong Wang research profile at UC San Diego. Overview and Stanford structural-biology training
A 2006 study by Dong Wang and collaborators examined structures of actively transcribing RNA polymerase II. The RNA polymerase trigger loop adopted a closed arrangement beneath a correctly positioned nucleoside triphosphate, contacting its base, sugar and phosphates. These observations suggested how recognition of the correct substrate could be coupled to formation of a new phosphodiester bond.[ref]
For example, recognizing only the nucleobase would leave an incomplete explanation of substrate choice: contacts with the sugar and phosphates also help position the incoming molecule. The structural comparison supplies specific interactions to test experimentally. A set of structures samples molecular arrangements; it does not by itself provide a frame-by-frame movie of the reaction.
Dong Wang
. Photo explicitly identified on the UC San Diego institutional profile for the transcription and DNA-repair researcher. Articles by others on the same topic
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