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FGF10 is a secreted fibroblast growth factor involved in developmental signalling between tissues. Its interaction with the FGFR2b isoform of FGFR2 can regulate epithelial outgrowth and organ formation. The response depends on receptor availability and the local signalling environment. A secreted ligand can therefore change tissue growth without acting as a structural component of the growing organ. ^[ref]

FGFR2 is a receptor tyrosine kinase in the fibroblast growth factor receptor family. Ligand-dependent activation connects an extracellular signal to intracellular phosphorylation pathways that influence development and cellular behaviour. Alternative receptor isoforms differ in ligand recognition; FGF10 is a ligand for the epithelial FGFR2b isoform. Thus expression of the generic receptor name alone does not specify every ligand response. ^[ref]