FGFR2 is a receptor tyrosine kinase in the fibroblast growth factor receptor family. Ligand-dependent activation connects an extracellular signal to intracellular phosphorylation pathways that influence development and cellular behaviour. Alternative receptor isoforms differ in ligand recognition; FGF10 is a ligand for the epithelial FGFR2b isoform. Thus expression of the generic receptor name alone does not specify every ligand response. [ref]
FGF receptor family by the IUPHAR-BPS Guide to Pharmacology. IUPHAR/BPS, FGF receptor family: FGFR2 ligands and isoforms
Articles by others on the same topic
There are currently no matching articles.