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Use the uniform Frankl-Wilson theorem: if $p$ is a prime number, $L\subseteq {\mathbb{F}}_p$ has $s$ distinct residues, $s\le \min \{r,n-r\}$, and an $r$-uniform set family $\mathcal{F}$ has distinct-member intersection sizes in $L$ modulo $p$ while $r\mathrm{mod}p\notin L$, thenHere is a polynomial method in combinatorics proof. For each $A\in \mathcal{F}$, form the intersection polynomialover ${\mathbb{F}}_p$, and use multilinear reduction on the Boolean cube so its degree is at most $s$. At the characteristic vector of $B\in \mathcal{F}$, this evaluates to zero for $A\ne B$ and is nonzero for $A=B$. Consequently these evaluation functions are linearly independent.

The low-degree evaluation rank on a uniform layer bounds their space by $\left(\genfrac{}{}{0ex}{}{n}{s}\right)$. To justify that step without division by a possibly zero residue, form the integer incidence matrix with rows $T\subseteq [n]$, $|T|\le s$, columns $r$-sets $B$, and entries $1_{T\subseteq B}$. Over the rational numbers, a row with $|T|=j$ equals ${\left(\genfrac{}{}{0ex}{}{r-j}{s-j}\right)}^{-1}$ times the sum of the rows of all $s$-sets containing $T$. Thus its rational matrix rank is at most $\left(\genfrac{}{}{0ex}{}{n}{s}\right)$. Every larger minor is an integer determinant equal to zero and stays zero modulo $p$, so the same upper bound holds over ${\mathbb{F}}_p$. This proves the theorem.

For the forbidden midpoint problem, split $\mathcal{A}$ according to whether its members contain coordinate 1. Leave the containing half unchanged; complement every member of the avoiding half. Both resulting families consist of $2p$-sets containing 1, and complementation preserves their internal intersection sizes becauseWithin either transformed family, distinct intersections lie between 1 and $2p-1$ and are not $p$. Their residues are therefore in $L=\{1,\dots ,p-1\}$, whereas the set-size residue is $2p\equiv 0$. Apply the Frankl-Wilson theorem to each half and add:The factor 2 comes from splitting into two families. The unsplit family can contain disjoint sets, whose intersection residue zero equals the set-size residue and prevents this direct application. Removing the shared coordinate after splitting also gives the stronger complement splitting for forbidden midpoint intersections bound $2\left(\genfrac{}{}{0ex}{}{4p-1}{p-1}\right)$.

For the construction, fix a $(p+1)$-set $B$ and let $R=[4p]\setminus B$, of size $3p-1$. The fixed-core construction avoiding midpoint intersections isTwo members of $\mathcal{F}$ intersect in at least $p+1$ points; the same is true for two complements. An intersection across the two halves has size $|X\setminus Y|\le p-1$. No intersection is $p$. The halves are disjoint because one contains all of $B$ and the other none, so