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For frequency-dependent transmission with homogeneous mixing, each member of the susceptible compartment experiences force of infection $\lambda =\beta I/N=\beta i$. Consequently the total flow into the infectious compartment is $\beta SI/N$ people per unit time. The constant $\beta$ combines the contact frequency and the chance that a relevant contact causes infection, and has units of inverse time. Holding the infectious compartment's fraction fixed holds each person's force of infection fixed when $N$ changes. An unnormalized mass-action infection convention instead writes the total flow as $bSI$, where $b=\beta /N$ has units of inverse person-time; these two coefficients must not be confused.

Homogeneous mixing assumes that contacts sample the whole modelled population without differences between groups or locations. In the SIR model, the chance that a sampled contact belongs to the infectious compartment is $i=I/N$. This assumption makes a frequency-dependent transmission rule depend on the overall infectious compartment rather than a graph of individual contacts. Structured contacts require a different mathematical model, such as a discrete SIR epidemic on a graph.

For frequency-dependent transmission, the closed SIR model is a system of ordinary differential equations for the fractions $s,i,r$:Here $\beta >0$ is the coefficient of frequency-dependent transmission, and $\gamma >0$ is the recovery rate, interpreted more generally as the removal rate. Both have units of inverse time. With a constant recovery rate, the associated individual time in the infectious compartment has an exponential distribution with mean $1/\gamma$; the SIR model does not require every person to spend exactly that long there. The fractions themselves have no units.^[ref]

For counts $S=Ns$, $I=Ni$, $R=Nr$, the same SIR model equations readThe factor $1/N$ keeps the same $\beta$ in both descriptions. Dropping it while keeping these units would fail dimensional analysis. Some existing SIR model variants use the unnormalized mass-action infection convention instead, including the SIR susceptible-recovered identity; their coefficient is $b=\beta /N$ in the notation used here.

Adding the SIR model equations gives $d(s+i+r)/dt=0$, a short proof of conservation of population. Nonnegative starting fractions stay nonnegative: the outflow from either the susceptible compartment or the infectious compartment vanishes when that group is empty, while $dr/dt\ge 0$. Thus the susceptible compartment can only shrink and the removed compartment can only grow.

For a concrete initial value problem, stipulateAt the start, the flow into the infectious compartment is $0.3\times 0.99\times 0.01=0.00297$ of the total per day, and the flow into the removed compartment is $0.1\times 0.01=0.00100$ of the total per day. Hence $di/dt=0.00197$ per day. If $N=1000$, these correspond to model rates of $2.97$ and $1.00$ people per day, and net growth $1.97$ people per day. A rate need not be an integer count of events on any particular day.

For this SIR model, the basic reproduction number isIt describes one introduced member of the infectious compartment in an otherwise wholly susceptible compartment. The instantaneous reproduction number at the actual starting state is $R_0{s}_0=2.97$, obtained by freezing the current conditions and the current susceptible compartment's fraction. More generally it is $R_{0}s(t)$ in this SIR model. The basic reproduction number is a ratio of two rates, so it has no units; $r_0$ is a different quantity, the initial removed compartment's fraction.

While $i>0$, its instantaneous relative growth isInitially this equals $0.3\times 0.99-0.1=0.197{\mathrm{day}}^{-1}$. Freezing $s\approx s_0$ gives the early exponential growth approximation $i(t)\approx 0.01e^{0.197t}$ with $t$ measured in days. It must fail as the susceptible compartment shrinks. An epidemic invasion threshold occurs at $R_0{s}_0=1$; if $i_0=0$, the deterministic SIR model stays at $i=0$ even above that threshold.