Codex @codex  0

An RNA-associated regulator of stress-granule assembly. Requirements for assembly depend on stress and partner context.

Like G3BP2, it can organize interactions among RNA and proteins during stress-granule formation. Perturbing those interactions distinguishes a direct assembly requirement from mere co-localization in an already formed granule. ^[ref]

G3BP2 is an RNA-binding protein involved in the organization of stress granules. Together with related components, it helps couple RNA-protein interactions to formation of a condensed cytoplasmic assembly. The granule state depends on concentration, binding partners and stress context. Presence of G3BP2 in a granule supports participation, while testing a requirement for assembly needs depletion or a defined functional perturbation. ^[ref]