G3BP2 is an RNA-binding protein involved in the organization of stress granules. Together with related components, it helps couple RNA-protein interactions to formation of a condensed cytoplasmic assembly. The granule state depends on concentration, binding partners and stress context. Presence of G3BP2 in a granule supports participation, while testing a requirement for assembly needs depletion or a defined functional perturbation. [ref]
G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits by Nancy Kedersha and others. 2016, G3BP-family interactions and stress-granule assembly
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